Gamma-aminobutyric acid (GABA) and cell proliferation: focus on cancer cells.

نویسندگان

  • M Watanabe
  • K Maemura
  • K Oki
  • N Shiraishi
  • Y Shibayama
  • K Katsu
چکیده

In addition to its role in the adult mammalian nervous system as an inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) is involved in the proliferation, differentiation, and migration of several kinds of cells including cancer cells. GABA is synthesized predominantly from glutamate by glutamate decarboxylase and exerts its effects via ionotropic GABA(A) receptors and/or metabotropic GABA(B) receptors. In this review, the current state of knowledge regarding the role of the GABAergic system in peripheral nonneuronal cell proliferation is described, and recent advances in elucidation of the mechanisms leading to cell proliferation are discussed.

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عنوان ژورنال:
  • Histology and histopathology

دوره 21 10  شماره 

صفحات  -

تاریخ انتشار 2006